amakuru

Kugira ngo uruhu rukore neza, birumvikana ko nta kabuza umuntu agomba kugira igitekerezo runaka ku bintu bigize uruhu, atari ukumenyekanisha gusa ibicuruzwa, ahubwo no ku bintu bigize uruhu. Uyu munsi, reka tuvuge ku "carnosine" y'ibintu bigize uruhu.

'Carnosine' ni iki?
Carnosine ni dipeptide igizwe na beta-alanine na L-histidine, ifite ingano nyinshi mu mitsi no mu bwonko. Carnosine ifite imiterere myinshi ya antioxydants kandi ishobora gukuraho uturemangingo tw’ubudahangarwa mu mubiri.

Uburyo 'carnosine' ikora
Carnosine ishobora kongera ubushobozi bw'uruhu bwo guhangana n'ibibazo, igakomeza ubuto bw'uturemangingo binyuze mu gukomeza imikorere y'uturemangingo mu gice cyose cy'umubiri no mu miterere ya radicals yigenga, igatuma uruhu rukora neza kandi rugahora rworoshye.

Uruhare rwa 'carnosine'
Carnosine ishobora kongera ubushobozi bw'uruhu bwo guhangana n'ibibazo, igakomeza ubuto bw'uturemangingo binyuze mu gukomeza imikorere y'uturemangingo mu gice cyose cy'umubiri no mu miterere ya radicals yigenga, igatuma uruhu rukora neza kandi rugahora rworoshye. Imiterere ya shimi yaL-carnosineni ukurema beta-alanine na L-histidine binyuze mu bikorwa bya carnosine synthase. Carnosine ifite amahirwe menshi yo gukoreshwa mu buvuzi, ubuvuzi, n'isuku bitewe n'ubushobozi bwayo bwo kurwanya antioxydants, ingaruka zo gukuraho radicals libre, chelation hamwe na transition metals, kurinda ubwonko, guteza imbere gukira kw'ibikomere, no kurwanya gusaza.

1. Ikoreshwa rya carnosine mu nganda z'ibiribwa
Igice cy'ingenzi cy'amavuta mu biribwa ni uruvange rwa aside irike glycerides zitandukanye. Bitewe n'uburyo aside irike glycerides idafite amavuta menshi ikora mu gihe cyo kubika, peroxide na aldehydes zinuka cyangwa aside karubokisilike zifite uruhererekane rugufi rwa karuboni zirakorwa. Kubwibyo, kurya ibiryo birimo peroxides birushaho gutuma lipide ziyongera mu mibiri y'abantu kandi bigatera indwara zitandukanye. Kubwibyo, hydroxyanisole ivanze, hydroxytoluene ivanze, propyl gallate, nibindi bikunze gukoreshwa mu gutunganya no kubika ibiryo kugira ngo birinde lipide ziyongera, ariko imikorere yabyo izagabanuka mu gihe cyo gushyushya ibiryo, kandi bifite uburozi runaka. L-carnosine ntishobora gusa gukumira ogisijeni y'ibinure neza, ahubwo inafite imikorere myiza mu mutekano no mu buzima. Kubwibyo, L-carnosine ni antioxydant y'agaciro kandi nziza mu biribwa.
2. Gukoresha carnosine mu buvuzi no mu buvuzi
(1) Karunosine na Antioxydant

Carnosine ntishobora gukoresha gusa umugozi wa imidazole N atome na peptide bond N atome ku bisigazwa bya histidine kugira ngo ikuremo iyoni z'icyuma kandi ikumire ogisijeni y'ibinure iterwa na iyoni z'icyuma, ahubwo na histidine iri ku ruhande rwa carnosine ifite ubushobozi bwo gufata radicals za hydroxyl. Ishobora gukumira ogisijeni y'ibinure iterwa na iyoni zitari iz'icyuma. Kubwibyo, nk'ikintu gifite imikorere myinshi ya antioxidant, carnosine ishobora kurinda uturemangingo tw'ingirabuzimafatizo kandi ikaba ikoresha radicals zidafite amazi zishonga. , ishobora gukumira ogisijeni y'ururenda rw'ingirabuzimafatizo. Ugereranyije n'izindi antioxydants za biological nka VC, carnosine ifite ubushobozi bukomeye bwa antioxydant. Uretse kubuza inzira ya ogisijeni y'ururenda rw'ingirabuzimafatizo, carnosine ishobora kandi gukumira urukurikirane rw'izindi reaction za peroxidation mu ngirabuzimafatizo zose, ni ukuvuga ko carnosine ishobora gukumira buri ntambwe ya ogisijeni mu ruziga rwose rwa peroxidation mu binyabuzima. Akamaro k'uturemangingo nka VC ni ukubuza ko udukoko twitwa free radicals twinjira mu mubiri, ni ukuvuga ko dushobora gusa gukumira inzira yo gusohora ogisijeni mu ngirabuzimafatizo, kandi ntacyo dushobora gukora ku dukoko twitwa free radicals twinjiye mu ngirabuzimafatizo.
(2) Karunosine n'igisebe cyo mu gifu

Igisebe cy’igifu ni indwara idakira ku isi, kandi ibintu byihariye bitera ibisebe ntibirasobanuka neza muri iki gihe, ariko indwara zigaragaza ko ibintu bikomeye (nk'aside yo mu gifu, gusohora pepsin, kwandura Helicobacter pylori) no gukumira cyangwa se mu turemangingo Biterwa no kudahuza kw'ibintu birinda (gusohora ibisebe, gusohora bikarubonate, gukora prostaglandin). Uburyo karemano bwo kurinda igifu ni: bukora urwego runini rw'umuyoboro w'igifu ukora nk'uruzitiro rwo kurinda uturemangingo mu gice cy'umubiri. Gusohora ibisebe mu gifu buri gihe birinda igifu, ariko gusohora ibisebe byinshi bishobora gutera ibisebe mu gifu. Ubushakashatsi bwagaragaje ko zinc-carnosine ifatwa n'ibiryo ishobora gukumira ibisebe neza, ishobora kubungabunga neza igifu n'uburyo bwayo karemano bwo kurinda, ibi biterwa n'imiterere ya carnosine irwanya ogisijeni, guhagarara kw'urukiramende, amategeko Imiterere y'ubudahangarwa bw'umubiri n'imyanya isanwa. Nk'uko byagaragajwe n'igerageza rya muganga, nyuma yo gufata zinc-carnosine mu byumweru umunani, 70% by'abarwayi bafashe uyu muti bagaragaje iterambere rigaragara, naho 65% by'ibisebe byo mu gifu byarushijeho kuba byiza binyuze mu gupima indwara.
(3) Kugenzura imisemburo ya karunosine n'ubudahangarwa bw'umubiri

Ubudahangarwa bw'umubiri ni imikorere y'umubiri ikomeza homeostasis kandi ikagenzurwa n'ibintu bikora mu mubiri mu binyabuzima. Ubudahangarwa bw'umubiri busobanura kuvura ubwoko bw'indwara ziterwa n'imikorere mibi y'ubudahangarwa bw'umubiri, kandi bukoreshwa mu kugarura ubudahangarwa bw'umubiri, kubuza kugabanuka kudasanzwe cyangwa guhagarika uburyo bwabwo bwihuse bwo kubikora. Inyinshi mu budahangarwa bw'umubiri zisanzwe zikorwa hakoreshejwe uburyo bwo gukora imiti, bufite uburozi n'ingaruka mbi. Ubushakashatsi bwagaragaje ko carnosine ifite imikorere yo guhindura ubudahangarwa bw'umubiri, kandi ni yo misemburo yonyine ikoreshwa mu guhindura ubudahangarwa bw'umubiri kugeza ubu, kandi yakoreshejwe cyane mu kuvura indwara zitandukanye n'indwara ziterwa n'ubudahangarwa bw'umubiri budasanzwe.