amakuru

Kubitaho neza kuruhu, byanze bikunze, byanze bikunze kugira igitekerezo runaka cyibigize, ntabwo kuzamura ibicuruzwa gusa, ahubwo nibigize ibicuruzwa. Uyu munsi, reka tuvuge kuri "karnosine" yibigize ibikomoka ku ruhu.

'Carnosine' ni iki?
Carnosine ni dipeptide igizwe na beta-alanine na L-histidine, ifite ibintu byinshi mumitsi no guhagarika ubwonko. Carnosine ifite antioxydants nyinshi kandi irashobora gukuramo radicals yubusa mumubiri.

Uburyo 'karnosine' ikora
Carnosine irashobora kongera imbaraga zuruhu, ikagumana imiterere yubusore ikomeza ibikorwa byutugingo ngengabuzima hamwe na radical radical yubuntu, guteza imbere umusaruro wa kolagen, kandi bigatuma uruhu rworoha.

Uruhare rwa 'karnosine'
Carnosine irashobora kongera imbaraga zuruhu, ikagumana imiterere yubusore ikomeza ibikorwa byutugingo ngengabuzima hamwe na radical radical yubuntu, guteza imbere umusaruro wa kolagen, kandi bigatuma uruhu rworoha. Imiterere yimiti yaL-karnosineni ugukora beta-alanine na L-histidine binyuze mubikorwa bya karnosine. Carnosine ifite amahirwe menshi yo gukoreshwa mubijyanye n'ubuvuzi, ubuvuzi, n'isuku bitewe na antioxydeant, ingaruka zo gukata ku buntu, chelation hamwe n'ibyuma by'inzibacyuho, neuroprotection, kuzamura ibikomere, no kurwanya gusaza.

1. Gukoresha karnosine mu nganda zibiribwa
Ibice byingenzi byamavuta mubiryo ni uruvange rwa aside irike ya glyceride. Bitewe nubusa bwibisubizo bya aside irike ya glyceride mugihe cyo guhunika, peroxide na aldehydes ihumura cyangwa acide karubasi ya acide ifite iminyururu ngufi ya karubone. Kubwibyo, kurya ibiryo birimo ibinure bya peroxide bizarushaho guteza imbere lipide peroxidisation mumubiri wabantu kandi bitera indwara zitandukanye. Kubwibyo, butylated hydroxyanisole, hydroxytoluene ya dibutylated, propyl gallate, nibindi bikunze gukoreshwa mugutunganya ibiryo no kubika kugirango birinde ibinure, ariko ingaruka zabyo zizagabanuka mugihe cyo gushyushya gutunganya ibiryo, kandi bifite uburozi runaka. L-karnosine ntishobora kubuza gusa okiside yibinure, ariko kandi ifite umutekano muke hamwe nubuvuzi. Kubwibyo, L-karnosine ni antioxydants y'ibiryo bifite agaciro kandi byiza.
2. Gukoresha karnosine mubuvuzi no kwita kubuzima
(1) Carnosine na Antioxidant

Carnosine ntishobora gukoresha gusa impeta ya imidazole N atom na peptide bond N atom kubisigisigi bya histidine kugirango ikoreshe ion ibyuma kandi ikabuza okiside yibinure iterwa na ioni yicyuma, ariko kandi na histidine kumurongo wuruhande rwa karnosine ifite ubushobozi bwo gufata radicals hydroxyl. Irashobora kubuza okiside yibinure iterwa na ion zidafite ibyuma. Kubwibyo, nkibintu byinshi birwanya antioxydants ikora, karnosine irashobora kurinda byimazeyo ururenda kandi ni amazi adashonga yubusa ya radical scavenger. , irashobora gukumira peroxidisation ya selile. Ugereranije nizindi antioxydants yibinyabuzima nka VC, karnosine ifite imbaraga za antioxydeant. Usibye guhagarika inzira ya peroxidisation ya selile ya selile, karnosine irashobora kandi guhagarika urukurikirane rwizindi ngaruka ziterwa na peroxidation yo mu nda, ni ukuvuga karnosine irashobora guhagarika intambwe zose ziterwa na okiside mumurongo wose wa peroxidisation mubinyabuzima. Uruhare rwa antioxydants nka VC ni ukurinda radicals yubusa kwinjira mu ngingo, ni ukuvuga ko zishobora gusa gukumira inzira ya peroxiside y’amazi ya selile, kandi ntacyo ishobora gukora kuri radicals yubuntu yinjiye mu kagari.
(2) Carnosine na ibisebe byo mu gifu

Indwara ya Peptic ni indwara ya sisitemu yo mu gifu idakira ku isi, kandi ibintu byihariye bitera ibisebe ntibisobanutse neza muri iki gihe, ariko indwara ya pathologiya yemera ko ibintu bikaze (nka acide gastric, pepsin secretion, Helicobacter pylori infection) no kwirinda cyangwa selile Byatewe na an ubusumbane bwibintu birinda (ururenda rwijimye, ururenda rwa bicarbonate, umusaruro wa prostaglandine). Uburyo busanzwe bwo kurinda igifu ni: bukora igicucu cyinshi cya mucosa gastrica ikora nkinzitizi yo kurinda ingirabuzimafatizo. Gukomeza gusohora ururenda rurinda igifu, ariko gusohora gukabije birashobora gutera ibisebe byo munda. Ubushakashatsi bwerekanye ko zinc-karnosine ifashwe nibiryo ishobora kwirinda neza ibisebe, irashobora gukomeza neza ubusugire bwigifu nuburyo bwayo bwo kurinda kamere, ibi biterwa na antioxydeant ya karnosine, guhagarika membrane, kugenga imiti ya farumasi yumubiri no gusana. Nk’uko ubushakashatsi bw’amavuriro bubitangaza, nyuma yo gufata ibyumweru umunani zinc-karnosine, 70% by’abarwayi bafashe ibiyobyabwenge bagaragaje iterambere ryinshi, naho 65% by’ibisebe byo mu gifu byatejwe imbere binyuze muri gastroscopi.
(3) Karnosine no kugenzura ubudahangarwa

Ubudahangarwa bw'umubiri ni imikorere ya physiologique ikomeza homeostasis kandi igengwa nibintu bifatika bifatika mubinyabuzima. Immunomodulator bivuga kuvura icyiciro cyindwara ziterwa no kudakora neza, kandi zikoreshwa mugusubiza ubudahangarwa bw'umubiri, kubuza kugabanuka kudasanzwe cyangwa guhagarika igisubizo cyihuse. Byinshi mubikingira immunomodulator bihuzwa nuburyo bwa synthesis ya chimique, bifite uburozi nibibi. Ubushakashatsi bwerekanye ko karnosine ifite imikorere yubudahangarwa, kandi nicyo kintu cyonyine gikora physiologique kiboneka kugeza ubu cyo gukingira indwara, kandi kikaba cyarakoreshejwe cyane mu kuvura indwara zitandukanye z’umubiri n’indwara ziterwa n’ubudahangarwa budasanzwe.