amakuru

Hydroxypropyl beta-cyclodextrin. hydroxypropoxy. HP-CD-CD ntabwo ifite gusa ibahasha nziza yibintu byinshi nka β-CD, ariko kandi ifite ibyiza byo gukama amazi menshi no kuzamura igipimo cyo kurekura hamwe na bioavailable yimiti ifunze muri vivo. Byongeye kandi, HP-β-CD ni ibiyobyabwenge bikoresha amakuru menshi y’umutekano yakusanyijwe kandi nta ngaruka mbi. HP-β-CD irashobora kandi gukoreshwa nka proteine ​​ikingira kandi ikomeza.

Hydroxypropyl beta-cyclodextrin ni umweru cyangwa umweru amorphous cyangwa ifu ya kristaline; Impumuro nziza, iryoshye gato; Kwinjiza cyane. Ibicuruzwa byoroshye gushonga mumazi, byoroshye gushonga muri methanol, Ethanol, hafi kutaboneka muri acetone, trichloromethane.

Gukemura kwahydroxypropyl -B-cyclodextrinmumazi nibyiza cyane, kandi urwego rwo gusimbuza 4 na hejuru rushobora kutumvikana namazi murwego urwo arirwo rwose, kandi rushobora no gushonga muri 50% Ethanol na methanol. Ifite isano ya hygroscopicity. Ariko ibikorwa byo hejuru ugereranije nibikorwa bya hemolytike ni bike. Ntabwo ifite uburakari ku mitsi kandi ni ikintu cyiza cyongera imbaraga kandi cyangiza imiti yo gutera inshinge.

Niki Hydroxypropyl beta-cyclodextrin ikoreshwa？

Mu rwego rwibiryo n'ibirungo

Hydroxypropyl beta-cyclodextrin irashobora kunoza ituze hamwe nigihe kirekire cyimikorere ya molekile zintungamubiri, gupfukirana cyangwa gukosora impumuro mbi nuburyohe bwa molekile zintungamubiri zibiryo, kandi bikazamura umusaruro nubuziranenge bwibicuruzwa.

Mu kwisiga

Ibikoresho fatizo byo kwisiga birashobora gukoreshwa nka stabilisateur, emulisiferi, deodorizeri, nibindi, bishobora kugabanya ubukangurambaga bwa molekile kama yo kwisiga kumubiri wuruhu hamwe nuduce twijimye, byongera imbaraga mubintu bikora, kandi bikarinda guhindagurika no guhumeka intungamubiri. . Ifite isano runaka ya hygroscopicity.

Mu rwego rw'ubuvuzi

Hydroxypropyl beta-cyclodextrinIrashobora kunonosora amazi yimiti idashobora gushonga, kongera umutekano wibiyobyabwenge, kunoza ibiyobyabwenge bioavailable, kongera imbaraga zo gutegura ibiyobyabwenge cyangwa kugabanya urugero, guhindura cyangwa kugenzura umuvuduko wo gusohora ibiyobyabwenge, no kugabanya uburozi bwibiyobyabwenge. Irashobora gukoreshwa nk'abatwara ibiyobyabwenge byo mu kanwa, inshinge, sisitemu yo gutanga imiti ya mucosal (harimo mucosa yo mu mazuru, rectum, cornea, nibindi), uburyo bwo gutanga imiti ya transdermal sisitemu yo gutanga imiti, imiti igamije lipofilique, kandi irashobora no gukoreshwa mu kurinda poroteyine kandi stabilisateur.