amakuru

Hydroxypropyl beta-cyclodextrin, izwi kandi nka (2-hydroxypropyl) -β-cyclodextrin, ni atome ya hydrogen iri mu matsinda ya 2-, 3-, na 6-hydroxyl y'ibisigazwa bya glucose muri β-cyclodextrin (β-CD) isimburwa na hydroxypropyl ikaba hydroxypropoxy. HP-β-CD ntabwo igira ingaruka nziza gusa ku bintu byinshi nka β-CD, ahubwo inafite ibyiza byo gushonga cyane mu mazi no kunoza igipimo cyo kurekura no kubona imiti yashyizwe mu bisebe mu mubiri. Byongeye kandi, HP-β-CD ni umuti ufasha mu gukusanya amakuru menshi y'umutekano kandi nta ngaruka mbi. HP-β-CD ishobora kandi gukoreshwa nk'uburinzi n'ubudahangarwa bwa poroteyine.

Hydroxypropyl beta-cyclodextrin ni ifu y'umweru cyangwa umweru idahinduka cyangwa ifu ya kristu; Nta mpumuro, iryoshye gato; Ituma amazi ahinduka cyane. Iki gicuruzwa cyoroshye gushonga mu mazi, cyoroshye gushonga muri methanol, ethanol, hafi ya cyose ntigishonga muri acetone, trichloromethane.

Uburyo bwo gushonga bwahydroxypropyl-B-cyclodextrinMu mazi ni byiza cyane, kandi igipimo cyo gusimbuza cya 4 no hejuru gishobora kuvangwa n'amazi mu rugero urwo arirwo rwose, kandi gishobora no gushonga muri ethanol na methanoli 50%. Ifite hygroscopicity runaka. Ariko imikorere y'ubuso n'imikorere ya hemolytic ni bike cyane. Nta gukabya imitsi kandi ni umuti mwiza wo kongerera imbaraga solvent n'umuti wo gutera.

Hydroxypropyl beta-cyclodextrin ikoreshwa iki?

Mu rwego rw'ibiribwa n'ibirungo

Hydroxypropyl beta-cyclodextrin ishobora kunoza uburyo molekyuli z’intungamubiri zihagaze neza kandi zikora neza igihe kirekire, igatwikira cyangwa igakosora impumuro mbi n’uburyohe bw’molekyuli z’intungamubiri z’ibiribwa, kandi ikanoza uburyo bwo gukora n’ubwiza bw’umusaruro.

Mu bijyanye no kwisiga

Ibikoresho fatizo by’ubwiza bishobora gukoreshwa nk’ibikomeza, ibitera imbaraga, ibikuraho impumuro mbi, nibindi, bishobora kugabanya uburyo molekile z’umwimerere zikoreshwa mu kwisiga ku ruhu no mu ruhu, kongera ubushobozi bw’ibintu bikora, no gukumira guhindagurika no gushonga kw’intungamubiri. Bifite ubushobozi bwo kugabanya ubwinshi bw’ibinure.

Mu rwego rw'ubuvuzi

Hydroxypropyl beta-cyclodextrinIshobora kongera ubushobozi bwo gushonga mu mazi y’imiti idashonga, kongera ubushobozi bwo gufata imiti neza, kongera ubushobozi bwo kuyikoresha, kongera ubushobozi bwo kuyitegura cyangwa kugabanya urugero rw’imiti, guhindura cyangwa kugenzura umuvuduko w’imiti, no kugabanya uburozi bw’imiti. Ishobora gukoreshwa nk’ifata imiti inyobwa, inshinge, uburyo bwo kuyikoresha mu mucosa (harimo mucosa y’izuru, rectum, cornea, nibindi), uburyo bwo kuyikoresha mu gukurura imiti mu mubiri, imiti ikoreshwa mu gukurura lipophilic, kandi ishobora no gukoreshwa nk’uburinzi n’ubudahangarwa bwa poroteyine.